Test Name: Uric Acid, Serum
Specimen Type: Serum
Specimen Required: 3-5 Cc Yellow Top Gel Vial
Day Performed: Daily
Reporting Time: 8 Hours STAT Reporting Time: 120 MINUTES
Methodology: Beckman Coulter AU480
CLINICAL SIGNIFICANCE:
High levels of uric acid can sometimes cause gout or kidney disease. Greater-than-normal levels of uric acid(hyperuricemia) may be due to:
- Acidosis
- Alcohol (ethanol) consumption
- Chemotherapy-related side effects
- Dehydration
- Diabetic ketoacidosis
- Excessive exercise
- Fructose consumption
- Hyperparathyroidism
- Hypothyroidism
- Lactic acidosis
- Lead poisoning
- Leukemia
- Medicines such as cyclosporine, diuretics, nicotinic acid, salicylates (low dose), tacrolimus
- Medullary cystic kidney disease
- Obesity
- Polycythemia vera
- Psoriasis
- Purine-rich diet
- Renal failure
- Toxemia of pregnancy
- Vitamin B12 deficiency
Lower-than-normal levels of uric acid may be due to:
- Fanconi syndrome
- Hereditary diseases of metabolism
- HIV infection
- Low purine diet
- Medicines such as atorvastatin, captopril, enalapril, fenofibrate, losartan, probenecid, and trimethoprim-sulfamethoxazole
- Syndrome of inappropriate antidiuretic hormone (SIADH) secretion
References:
- Dalbeth N. Clinical features and treatment of gout. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O’Dell JR, eds. Firestein & Kelley’s Textbook of Rheumatology.11th ed. Philadelphia, PA: Elsevier; 2021: chap 101.
- Edwards NL. Crystal deposition diseases. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020: chap 257.
- Weisbord SD, Palevsky PM. Prevention and management of acute kidney injury. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector’s The Kidney.11th ed. Philadelphia, PA: Elsevier; 2020: chap 29.