Test Name: Calcium Ionized, Blood
Specimen Type: Serum
Specimen Required: 3-5 Cc Yellow Top Gel Vial
Day Performed: Daily
Reporting Time: 8 Hours STAT Reporting Time: 120 MINUTES
Methodology: Beckman Coulter AU480
CLINICAL SIGNIFICANCE:
Higher-than-normal levels of ionized calcium may be due to:
- Decreased levels of calcium in the urine from an unknown cause
- Hyperparathyroidism
- Hyperthyroidism
- Milk-alkali syndrome
- Multiple myeloma
- Paget disease
- Sarcoidosis
- Thiazide diuretics
- Thrombocytosis (high platelet count)
- Tumors
- Vitamin A excess
- Vitamin D excess
Lower-than-normal levels may be due to:
- Hypoparathyroidism
- Malabsorption
- Osteomalacia
- Pancreatitis
- Renal failure
- Rickets
- Vitamin D deficiency
References:
- Bringhurst FR, Demay MB, Kronenberg HM. Hormones and disorders of mineral metabolism. In: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020: chap 29.
- Klemm KM, Klein MJ, Zhang Y. Biochemical markers of bone metabolism. In: McPherson RA, Pincus MR, eds. Henry’s Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022: chap 16.
- Thakker RV. The parathyroid glands, hypercalcemia, and hypocalcemia. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020: chap 232.